Checkpoint Inhibitors Side Effects

Paying careful attention to potential symptoms is therefore crucial.

Checkpoint inhibitors side effects.

Fatigue weakness nausea confusion headache loss of appetite vision problems fever. Common side effects associated with currently approved checkpoint immunotherapies may include but are not limited to. Fatigue rash colitis infusion related reactions diarrhea asthenia arthralgias constipation decreased appetite cough dyspnea headache insomnia nausea pain including in the abdomen back and musculoskeletal system peripheral edema pneumonitis radiation pneumonitis pruritus pyrexia vomiting and weight loss. Other immune checkpoint inhibitors are under clinical evaluation.

Mp inflammatory reactions involving the skin and the gastrointestinal tract are among the most common adverse events seen with checkpoint inhibitors. Diarrhea pneumonitis inflammation in the lungs rashes and itchiness problems with some hormone levels kidney infections. Checkpoint inhibitor associated neurological side effects are rare but potentially life threatening. He says he figures these are just normal side effects of his medication.

However immune checkpoint blockade can lead to the breaking of immune self tolerance thereby inducing a novel syndrome of autoimmune autoinflammatory side effects designated as immune related adverse events mainly including rash colitis hepatitis and endocrinopathies. After about six months of therapy john tells you that over the past four weeks he has been experiencing increased fatigue weight gain insomnia and constipation. Common side effects of immune checkpoint inhibitors include. The most common side effects of checkpoint inhibitors are.

On average symptoms appear around nine weeks after starting treatment and may include.